The 2005 movie Mr. and Mrs. Smith stars Brad Pitt and Angelina Jolie with Vince Vaughn. Although it suffers from hero-gun-syndrome (like in the old Westerns where the hero could shoot villains with a revolver from 300ft while riding a horse, but the whole hapless collection of bad guys could only hit objects near the hero, or, if they were lucky, graze or wing the hero), it is a cute movie with some nice snippets of dialogue, and there seems to be some chemistry between Mr. and Mrs. Pitt.

For a wickedly popular sequel, the producers need to throw a bunch a money to Jennifer Aniston to play a character hunting down the Smiths with the support of Vince's character. The backstory would have the Jennifer character having some previous romantic history with the Brad character.